Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis
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Institutional Subscription. Free Shipping Free global shipping No minimum order. Preface Chapter One. Introduction 2. Cellular Functions of the Exosome 3. Composition of Exosomes and Their Related Complexes 4. Exosome Cofactors 5. Concluding Remarks References Chapter Two. Plant Exosomes and Cofactors 1. Composition of the Plant Exosome Core Complex 3.
Exosome-Related Activities and Cofactors in Plants 4. Impact of Exosome-Mediated Degradation in Plants 5. Final Remarks References Chapter Three. Global Architecture of the Eukaryotic Exosome Core 3. RRP44 and the Component Exosome 7. Conclusions References Chapter Four. Localization of XRN1 in Cells 7. Regulation of XRN1 Activity However, it should be noted that this latter scenario is a model that still requires experimental verification. A prominent feature of the m 7 G cap is its role in translation initiation by recruitment of the initiation complex onto the mRNA [ 51 ].
Translation initiation complex assembly onto an mRNA can also occur by m 7 G cap-independent mechanisms [ 52 ]. Nevertheless, insight into potential deNADding enzymes exist. Furthermore, the deNADding activity of both proteins is more robust than their respective incomplete cap decapping activities. These observations suggest Edc3 may function as a deNADding enzyme.
Processing of microRNA primary transcripts requires heme in mammalian cells.
In the absence of iron, the aconitase enzyme is endowed with RNA-binding properties to bind a stem loop structure and influence mRNA stability and translation [ 60 , 61 ]. The discovery of the m 7 G cap on mRNAs over four decades ago opened a new and exciting area of research for RNA biology and the control of mRNA fate through its addition and removal, that still continues to date. If so, would it modulate mRNA turnover, translation or localization? However, based on the precedent in mammalian cells where there are multiple m 7 G decapping enzymes [ 22 ], additional deNADding enzymes with selective specificities are expected.
The road ahead will undoubtedly be just as exciting and full of surprising new discoveries to be uncovered. Insightful suggestions and critical reading of the manuscript by Drs. Xinfu Jiao and Bryce Nickels are greatly appreciated. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript.
The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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- Primary MicroRNA Processing Assay Reconstituted Using Recombinant Drosha and DGCR8.
Trends Cell Biol. Author manuscript; available in PMC Jun 1. PMID: Megerditch Kiledjian. Megerditch Kiledjian Dept. Megerditch Kiledjian, Dept. Copyright notice. The publisher's final edited version of this article is available at Trends Cell Biol. See other articles in PMC that cite the published article. Open in a separate window. Figure 1. Figure 2. Adenosine-containing nucleoside metabolites Structure of each metabolite is shown. Figure 3.
Figure 4. Concluding Remarks The discovery of the m 7 G cap on mRNAs over four decades ago opened a new and exciting area of research for RNA biology and the control of mRNA fate through its addition and removal, that still continues to date. Outstanding Questions. What are the enzymes and the pathway involved? Acknowledgments Insightful suggestions and critical reading of the manuscript by Drs.
Eukaryote RNase P and RNase MRP
Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. References 1. Furuichi Y, et al. Wei CM, et al. Wang Z, Kiledjian M. Hamm J, Mattaj IW. Monomethylated cap structures facilitate RNA export from the nucleus. Lamond AL. The trimethyl-guanosine cap is a nuclear targeting signal for snRNPs. Trends Biochem Sci. Adams JM, Cory S. Wei C, et al.
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